Endocrine Abstracts

Objective: In last decades prevalence of type 2 diabetes mellitus (DM) in children and young people worldwide has been reported increase. It is necessary to know according to biochemical and genetic characteristics the frequency of DM no corresponding to type 1 in our population. The objective of this study was to determine the prevalence of mutations on hepatic nuclear factor 1 [alpha], and 4 [alpha] in diabetic patients younger than 35 years old with features of clinical aut...

Introduction: Diabetes is increasing its prevalence as an enhancement of treatment options arises and mortality declines. Pancreas transplantation has been postulated as one of them, specifically indicated for cases with end-stage renal failure where kidney transplantation is required besides. It has been analysed whether there is a clinical benefit in terms of quality of life (QoL) in patients undergoing pancreas-kidney transplantation (PKT) compared to dyalisis population or...

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...